I can imagine it'd be an issue if you ever wanted to put the ball wide. I'd still love to see that two-man wrecking ball though. You'd seriously wear down some teams in the middle and would be a decent way of muscling up on a Ma'a Nonu-type for example.
We're going to need to win the midfield if we want to go wide on Wales or England anyway.
Wales run their defense outside-in and almost always have a shooter in the 13-15 channel to try and cut off any wide play on early phases, shepherding the ball towards the midfield. It lets them cover up the lack of pace in their backline and make the most out of their uber-high work rate 6/7/8.
England will just jockey out and attempt to flood rucks (especially if we're running the Cheikaball pattern) or push the runners towards touch and try to shut us down at the lineouts, which is a very real possibility depending on which orcs they pull out of Mordor. With their current locking stocks they could throw Lawes on the blindside and really put us under pressure at every LO - and if they get away with the farcical bullshit they've been pulling at the scrum for the past few seasons, it could get really ugly.
To'omua is still probably our best option at 12 either way, if he can manage to stay healthy. Kerevi's defensive reads would be a major concern at 12 or 13 but it's not like TK has never been pantsed at test level either.
Having QC (Quade Cooper) healthy and in-form would definitely make the bash brothers center pairing more viable on attack. I don't think there's anyone else with the speed/flatness/length of pass to consistently skip out the centers and involve the back-three without constantly risking an intercept. He works especially well with big runners coming off either shoulder as well.