Selectors have stuck with the side which defeated Queensland 30-28 in the season opener on Saturday night, however two players from that team were forced out of the squad to head to the Republic.
Deep bone bruising sustained during his debut match will see lock Cam Jowitt miss the tour through injury, however he is expected to be fit to return when the squad completes its tour.
Flanker Dean Mumm was also forced out of the squad after being suspended for two matches at a SANZAR Judicial hearing on Sunday after being found guilty of charging.
2009 Wallaby tourists Dave Dennis and Rob Horne have been selected along with young prop Dan Palmer.
Former Emerging Springbok Hendrik Roodt returns to his homeland with hopes of making his Super 14 debut, while two other rookies have bolted into the squad.
2009 Tooheys New Shute Shield Rookie of the Year Locky McCaffrey has been named as cover in the back row following Mumm's suspension, while speedster Peter Betham earns his spot after impressing in the trials.
The Tahs have fond memories of the Republic having finished 2009 by becoming the first Australian or New Zealand team to win three matches back-to-back in South Africa, and they enter the tour having won their last five matches away from home.
The squad flies to Johannesburg on Monday morning before transferring to Cape Town.
HSBC Waratahs South African Touring Squad
Backs (12): Sosene Anesi (TBA), Berrick Barnes (TBA), Kurtley Beale (Northern Suburbs), Peter Betham (Sydney University), Luke Burgess (Sydney University), Tom Carter (Sydney University), Daniel Halangahu (Sydney University), Josh Holmes (Warringah), Rob Horne (Southern Districts), Drew Mitchell (Balmain), Rory Sidey (West Harbour), Lachie Turner (Eastwood).
Forwards (14): Al Baxter (Northern Suburbs), Will Caldwell (Sydney University), David Dennis (Sydney University), Kane Douglas (Southern Districts), Damien Fitzpatrick (Eastwood), Sekope Kepu (Randwick), Locky McCaffrey (Eastwood), Ben Mowen (Randwick), Dan Palmer (Southern Districts), Wycliff Palu (Manly), Tatafu Polota-Nau (Parramatta), Benn Robinson (Eastwood), Hendrik Roodt (Gordon), Phil Waugh [c] (Sydney University).