Adrian Jacobs has been ruled out of action for an extended period after suffering a dislocated shoulder during the Sharks' win over the Hurricanes at the weekend.
It's a big blow for the Sharks, as the Springbok centre had just started to find some form after being given an extended run in the number thirteen jersey, but his involvement in the Super 14 may well be over, with Waylon Murray the likely candidate to step into the outside centre berth.
Veteran lock Johann Muller is also still unavailable after missing last Saturday's match with a fractured finger, but otherwise coach John Plumtree said the team was "not in bad shape", with inside centre Riaan Swanepoel - who also sustained a blow to the shoulder at the weekend - expected to be ready to face the Reds.
Assessing the Sharks five-match overseas tour, Plumtree reflected on the positives and negatives that came out of the results in Australia and New Zealand.
"Scoring back-to-back wins was reward for a lot of hard work," he explained of the victories over the Highlanders and Hurricanes on successive weekends.
"Sometimes you work really hard and you get nothing and in Australia we were unlucky not to get a result there, particularly in the Waratahs game when after 72 minutes we were ahead. Then in the Brumbies game where we gave away a penalty and lost the match.
"It was a tough tour, but the boys never gave up. We talked about sticking together, we knew there was a lot of criticism back home and that's understandable."
Plumtree once more rubbished claims of a rift in the camp questioning the source, truth or value in publishing incorrect information.
"People tried to fracture us with media reports about myself and the job, and the unhappiness in the camp, but we decided to stick tight and work really hard; the last two weeks was really good reward," he said.
"As to the report about the Du Plessis brothers being behind a split, I don't know where people get this from. It is outsiders talking about us, they're not allowed in so I don't know where they're getting it from.
"John and Bismarck and Jannie are good mates. But the reports go on and on about these three guys, it's getting boring. Whenever there is an issue or a loss, they go to this.
"I'm not quite sure why that is."
Commenting on reports of his coaching job being in jeopardy, Plumtree explained that he hasn't gotten around to signing anything just yet.
"There is quite a bit more on my mind at the moment with rugby so let's wait and see," he said.
"The job's been talked about and my extension, but we discussed it before touring. I can understand that people will talk about it (replacing a coach) because my responsibility is to get results and to the team, a coach's life is like that.
"This time last year they were talking about Ewen MacKenzie getting the sack from the Waratahs, this time it's about me getting the sack. You just accept that that's the way it is."