I still don't understand how or why people would select Timani, the guy is a passenger most of the game. He can put on a big hit, but carrying he doesn't use his weight, and he slipped or missed more tackles than he made from my viewing. Useless in the lineout as well. Make him get the bread and butter of his position (lineout, rucks) at provincial level before letting him go close to the national team again.
With Simmons out, I'd start Douglas with Horwill. Fardy is likely out, so that means Mowen at 6, McCalman at 8. I'd be tempted to give Hooper a rest and put Gill at 7 with Hooper on the bench. Sadly, this means that Timani makes the bench, unless you want to carry Dennis as the spare lock.
I'd also rotate the props, at the very least start Kepu over Alexander, but also Robinson over Slipper.
I'd like to drop Genia, but I'd pick Phipps if that were the case. White just kicks too much. The only other change in the backline I'd make is Tomane for Cummins.
One thing: too much aimless kicking. Folau and To'omua had good games otherwise, but they kicked too much and too often let them English return with interest. Genia falls in here too, but his game otherwise was pretty poor.
Why did we revert to a Deans style kick everything for the English game after doing it differently in the RC? I would hate to see that sort of aimless play for the Italy game.