I was really impressive with Bell in the last game, happy to see him start for the injured Slips, and if we are going that route I'd be tempted to start Tupou along side him because they look to work well together.
Assuming LSL (Lukhan Salakaia-Loto) is fit he's straight back in along side Phillip, probably Ned off the bench, and Simmons can go to England a bit early.
I am still unconvinced with Isi, he was good in the Aus A games, but he's still very limited in what he brings to the table. He's weak in the rucks, he's not particularly impressive in defense, given that I'd probably have a look at him on the bench.
I'm still not sure what our best back row is, as I've said previously, I'd love to see McReight given a run at 7, but Hooper will be starting there. So form there, Wilson has got to start he's been too good not to start him. Then we are left with 6, I'd probably be looking at Wright I think he's more robust than Pete Samu both in his ruck work and in his ball running. IMO Samu and Hooper fill the same agile ball running need so Wright would be a little more in the thick of things than Samu but that's given we haven't seen how they are all training etc. So I'd have Wright or Samu at 6.
Backs
O'Connor starts at 10 (if fit), with Hunter & Jordie in the centers. (how impressive has Hunter been -- seriously!) Hodge to 15, with whatever two of the three wingers take your fancy.
I'd tend for a 6/2 split probably with Banks being the other back along with Tate (assuming White isn't as slow as he was last game). We are going to neeed to front up with the forwards. perhaps you take the other of Wright or Samu with the extra bench spot.